Seven benzimidazole pesticides combined at sub-threshold levels induce micronuclei in vitro
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Seven benzimidazole pesticides combined at sub-threshold levels induce micronuclei in vitro
Benzimidazoles act by disrupting microtubule polymerisation and are capable of inducing the formation of micronuclei. Considering the similarities in their mechanisms of action (inhibition of microtubule assembly by binding to the colchicine-binding site on tubulin monomers), combination effects according to the principles of concentration addition might occur. If so, it is to be expected that ...
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ژورنال
عنوان ژورنال: Mutagenesis
سال: 2013
ISSN: 1464-3804,0267-8357
DOI: 10.1093/mutage/get019